2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-130599
    Hydroxy-PEG2-CH2-Boc 149299-82-1
    Hydroxy-PEG2-CH2-Boc is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
    Hydroxy-PEG2-CH2-Boc
  • HY-140257
    NH-bis(PEG3-Boc) 1814901-03-5 98.0%
    NH-bis(PEG3-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH-bis(PEG3-Boc)
  • HY-141131
    Propargyl-PEG2-beta-D-glucose 2353409-73-9 98.0%
    Propargyl-PEG2-beta-D-glucose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Propargyl-PEG2-beta-D-glucose
  • HY-132094
    Azido-PEG9-S-methyl ethanethioate 2148986-33-6 98.18%
    Azido-PEG9-S-methyl ethanethioate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG9-S-methyl ethanethioate is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG9-S-methyl ethanethioate
  • HY-140541
    Tri-(PEG1-C2-acid) 1381861-95-5
    Tri-(PEG1-C2-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tri-(PEG1-C2-acid)
  • HY-140007
    Acrylate-PEG-NH2 (MW 2000)
    Acrylate-PEG-NH2 (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Acrylate-PEG-NH2 (MW 2000)
  • HY-135930
    Boc-NH-PEG10-CH2CH2NH2 1347704-59-9 ≥98.0%
    Boc-NH-PEG10-CH2CH2NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG10-CH2CH2NH2
  • HY-130231
    m-PEG2-acid 149577-05-9
    m-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG2-acid
  • HY-42617
    Hydroxy-PEG4-CH2-Boc 169751-72-8
    Hydroxy-PEG4-CH2-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Hydroxy-PEG4-CH2-Boc
  • HY-W013907
    11-Bromoundecan-1-ol 1611-56-9
    11-Bromoundecan-1-ol is a PROTAC linker. 11-Bromoundecan-1-ol can be used to synthesize PROTACs, such as PROTAC GPX4 degrader-4 (HY-174086).
    11-Bromoundecan-1-ol
  • HY-140758
    Azido-PEG9-NHS ester 2801772-87-0 98.0%
    Azido-PEG9-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG9-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG9-NHS ester
  • HY-138756
    PC DBCO-PEG4-NHS ester 2055025-02-8
    PC DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PC DBCO-PEG4-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    PC DBCO-PEG4-NHS ester
  • HY-141405
    m-PEG7-4-nitrophenyl carbonate 678150-56-6
    m-PEG7-4-nitrophenyl carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG7-4-nitrophenyl carbonate
  • HY-130621
    OTs-C6-OBn 126519-80-0 98.07%
    OTs-C6-OBn is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTAC SGK3 degrader-1 (HY-125878).
    OTs-C6-OBn
  • HY-140284
    DBCO-PEG6-amine 2353409-98-8
    DBCO-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG6-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG6-amine
  • HY-144081
    HO-PEG18-OH 4445-03-8 98.0%
    HO-PEG18-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HO-PEG18-OH
  • HY-133382
    DSPE-PEG46-DBCO
    DSPE-PEG46-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DSPE-PEG46-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DSPE-PEG46-DBCO
  • HY-140858
    Azido-PEG4-4-nitrophenyl carbonate 1422540-98-4 98.88%
    Azido-PEG4-4-nitrophenyl carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-4-nitrophenyl carbonate is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-4-nitrophenyl carbonate
  • HY-141208
    Hydroxy-PEG1-CH2-Boc 287174-32-7 99.49%
    Hydroxy-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG1-CH2-Boc
  • HY-130555
    PEG8-Tos 886469-23-4
    PEG8-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    PEG8-Tos
PROTAC Linkers Isoform Comparison

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